English
norskBlar i forfatter "Sætre, Thomas"
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On indications for cancer immunotherapy: A review of current practice for immunology-based indications
(Master thesis; Mastergradsoppgave, 2021-08-23)Knowledge of tumor immunology and immune escape mechanisms was the basis for developing immune checkpoint inhibitors (ICI) for cancer therapy. These target and block checkpoint molecules commonly implicated in tumor immune escape by overexpression, such as PD-1, its ligand, PD-L1 or CTLA-4. Use of ICIs has been approved mostly for treatment of advanced disease, some without any requirement ... -
Recombinant T-cell receptors from HPA-1a specific T-cells
(Mastergradsoppgave; Master thesis, 2022-02-01)Fetal- and neonatal alloimmune thrombocytopenia is a condition that can cause hemorrhage and potential brain damage or death in neonates. It is most often a result of maternal alloantibodies specific for fetal Human Platelet antigen 1a (HPA-1a) that destroy fetal platelets. The recognition of the HPA-1a peptide-MHC complex by T-cells involve a peculiar form of T-cell receptor peptide-MHC ...
